Shenzhen is large enough that the right district matters more than a hotel's generic “central” label. Put your main activity, arrival hub and departure point on one map, then choose a base that reduces repeated transfers.
Futian for connections; Houhai for new culture
Futian works for civic districts, business appointments and rail connections. If your trip centers on the Shenzhen Bay Culture Square and nearby waterfront, a Houhai or Shenzhen Bay base in Nanshan cuts repeated cross-city travel. Check the precise hotel-to-station walk; large complexes can make a short map distance misleading.
Nantou and Shekou for different evenings
Near Nantou Ancient Town, the draw is a mix of historic fabric and newer independent shops described in the city's Nanshan guide. Shekou offers a slower waterfront and a more international dining mix. They are different experiences even within western Shenzhen. Check the route from the hotel to the airport, a meeting venue or ferry terminal before choosing based on a photograph.
Luohu for a specific connection
Luohu can be practical if your itinerary uses that rail or border area. It should not be chosen solely because you intend to visit Hong Kong: the best crossing depends on your actual onward route and its current operating conditions.
Before paying, verify the Chinese address, nearby metro exit, late check-in and whether the property can register your travel document. Ask about noise if the room overlooks a major road or nightlife street. For a very short stay, make the next morning's departure the deciding factor.